Thyrotropin-releasing hormone selectively depresses glutamate excitation of cerebral cortical neurons.
نویسندگان
چکیده
The microiontophoretic application of thyrotropin-releasing hormone causes a selective reduction in neuronal excitation evoked by L-glutamate but not by acetylcholine in rat cerebral cortex. Thyrotropin-releasing hormone has no influence on the activity of acetylcholinesterase or on choline uptake and release from cerebral synaptosomes. This evidence for a selective interaction between a centrally acting peptide and an excitatory amino acid neurotransmitter may indicate a specific locus of thyrotropin-releasing hormone action at glutamate-activated receptor sites.
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عنوان ژورنال:
- Science
دوره 205 4412 شماره
صفحات -
تاریخ انتشار 1979